The Car T Cells Essay - 1282 Words

-What are CAR-T cells? Describe their structure. Car T-cells are more formally known as chimeric antigen receptors. These cells are genetically modified t-cells that are designed to target tumor cells. These CAR t-cells work by circulating through the blood looking for cells that they can bind to. The receptors of these cells are specifically designed to recognize a pattern that is common cancer. Once they cell comes into contact with the specific receptor, cell will then attack and destroy the cancer, but also can tell the rest of the body that there is a problem. The additional hope is that the CAR-T cells will create memory cells within the body as a normal T-cell. In the simplest explanation, CAR-T cells are genetically modified to attack cells the body would otherwise not recognize. These cells are recombinant receptors that have been developed specifically for this purpose. These CARs are usually composed of an extracellular antigen recognition receptor that is attached by a spacer to a transmembrane domain. Around these transmembrane domains could be additional domains that function as co-stimulator to produce a further immune response. In a normal t-cell, there is a requirement of an MHC molecule to bind and recognize the antigen, however, the CAR T-cells are capable of overcoming the limitation. So CAR T-cells are able to bind directly and independent of this system allowing the cell to read a much diverse pool. -How are they generated for clinical use? These cellsShow MoreRelatedCar T Cell Therapy : A Revolutionary Treatment From The Area Of Immuno Oncology1664 Words   |  7 PagesCAR-T Cell Therapy CAR-T cell therapy is a revolutionary treatment from the area of immuno-oncology. It is the most recent form of therapy to be hailed as a ‘miracle cure’ for cancer and is one of the most impressive forms of immunotherapy to date. CAR-T cell therapy takes advantage of our own immune system and uses it to fight cancer, the second leading cause of death in the world. It is a form of immunotherapy that also intertwines with gene therapy, and cell therapy. CAR-T cell therapy is a deviationRead MoreCauses And Treatment Of Pancreatic Cancer1385 Words   |  6 Pagessteps known as pancreatic intraepithelial neoplasia. This is the most prominent stage of cancer. During the early steps, slight changes are seen in a small number of genes. In the later steps, there are abnormalities in several genes and the duct cells become dysfunctional. The most common DNA changes in these conditions affects the KRAS oncogene. KRAS is the mutated gene in PDAC and this gene is said to drive cance r development and progression. 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CRISPR is versatile in t hat any target sequence can be modified by simply altering the gRNA sequence. In addition, multiple genes can be edited at the same time with great specificity (Cong 88-89). The convenience and accessibilityRead MoreIs Inattentional Blindness So Different Between The Two Tasks?1040 Words   |  5 Pagesresearchers wanted to see why inattentional blindness is so different between the two tasks. To test this participants were placed in a car that had been modified for the lab, to work with a driving simulation and eye trackers. The participants were also equipped with a hand a hands free phone before the task began. The dual task group were to do the driving task with a cell phone was compared to single task drivers who just did the driving task. 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Most accidents involving cell phones wouldn t have happened if the driver wasn t distracted. When we drive that should be the only activity we are doing. Posted by: Gri5Helpful Report Post Like Reply 0 0 Cell phone usage while

Criminology Paper Free Essays

To discuss further, the theory of Sampson and L pub supposes that the individual characteristics of a person are not the sole reason for his early delinquency and deviant behavior later in his life. There are social circumstances that may modify the behavior Of other persons while others proceeds with offending. There are three main components proposed in the age-graded life-course theory of Sampson and Lab. We will write a custom essay sample on Criminology Paper or any similar topic only for you Order Now First, the delinquency in childhood and adolescence can be explained by their informal relation with their family as well as the environment they have at school. These informal relations they build within their family and at school as well as the social controls coming from these two [family and school] intervene with the micro- level structural context of the children (Sampson Lab, 1992). Second, in different realms of life, the antisocial behavior from childhood through adulthood continues. Lastly, the informal social attachments that individuals develop to their family and employment during adulthood explicate modifications in criminality over their life in spite Of their early childhood tendencies (Sampson Lab, 1992). The most crucial findings of Sampson and Lab is that the social attachments that individuals develop during adulthood increase some people’s social capital, thus leading them to discontinue from most types of aberrant behavior. The theory further discussed how deviant behavior of individuals mitigate as they build social bonds to their spouse or coworkers. People’s attachment to their spouse or coworkers increases their self-control that leads to their distance from committing offenses. In the article of Sampson and Lab, they also discuss what trajectories, transitions, and turning points are. A trajectory, as explained in the article, is â€Å"a pathway or line of development over the life span such as workable, marriage, parenthood, self-esteem, and criminal behavior†Ã¢â‚¬Ëœ (Sampson Lab, 1992, p. 66). In other words, trajectories are the â€Å"long-term patterns and sequences of behavior† (Sampson Lab, 1992, p. 66). Transitions, on the other hand, are the specific events in the life of a person. Good examples of transitions are first marriage or first job (Sampson Lab, 1992). These transitions are implanted in trajectories. Transitions are the changes that are more or less sudden. The close causal connection of trajectories and transitions may create what is called a turning point. A turning point refers to a â€Å"change in the life course† (Sampson Lab, 1992, p. 66). It involves a certain experience, event, or awareness that leads to the change in the pathway or trajectory of a person over the long-term. According to Sampson and Lab, school, work, marriage, the military, and parenthood are examples of social institutions and triggering life experiences that may change trajectories (1992). The concepts of trajectory, transition and turning points re important in the study of crime because they help in understanding the dynamics of life course. From the theories presented by Sampson and Lab, as well as by Cottonseeds and Hirsch, life course is a path, and the understanding of trajectories and turning points help us to give meaning to the different factors that intervene and disturb the path of a person’s life course that may lead him to developing deviant or criminal behaviors. Looking at the trajectories of a person, one can ascertain the different relationships that the person has developed throughout time, thus causing IM to becoming what he is in the present time. Trajectories will help us determine the environment that a person has been into, thus leading him to develop characteristics and personalities he has presently. Transitions, on the other hand, help determine whether or not the timing between one event and the happening of another event is enough for a person to adjust This adjustment is important because lack of this may lead a person to develop deviant behaviors. Turning points, or changes in life trajectories, are very crucial in the study of crime because these are often what cause children, or managers, or even adults to exhibit or develop aberrant behaviors. These turning points, such as divorce of parents, retirement, or death, if will not match the behavior of a person may lead to delinquent behaviors. While Sampson and Lab speak of individual’s characteristics, social circumstances, as well as social bonds in understanding the criminality of a person, Cottonseeds and Hirsch, in their â€Å"general theory of crime†, propose that the imprudence and criminality of a person can be anticipated merely by looking at the lack of self-control of a person (Sampson Lab, 1992). They et aside the possibility of the other life and social factors that may intercept in the development of deviant behavior of a person. Nonetheless, Cottonseeds and Hirsch admit that although the personality of a person, for example his lack of self-control, does not change through time, the connection between self-control and crime is susceptible to change. The concept of life-course perspective of Cottonseeds and Hirsch is inversely linked to the level of self-control of a person. According to them, a person’s self-control is what shapes his agency in a manner that he tends to choose to e part of an environment that counterparts his level of self-control. The life course perspective of Sampson and L pub has been recognized by Cacao and Kennedy in explaining social control theory in general. Cacao and Kennedy agree that life course perspective is different from the other perspectives about social control and criminality because it acknowledges how different events or factors in the life course of people affect their progress at different times. By reconciling two contradicting findings in the field of crime research, one finding proposes that adult criminality is strongly impacted by patterns of childhood behavior while the other finding puts forward that changes in the life of people impact their tendency of criminality, Sampson and Lab are able to provide an explanation as to whether or not the propensity to commit an offense changes or remains the same over the life course of people (Cacao Kennedy, 2011). Cacao and Kennedy further say that the principles laid in the life course perspective are important in understanding the different informal social control present or become present in the life course of an offender that lead to the modification of a arson’s criminal involvement (2011). Additionally, the life course approach is a useful tool in ascertaining how changes in crime pattern of people across their life course are being affected with the opportunities and circumstances that they face as they move forward in life. In general, the life course perspective theory’ is related to the social control theory in general with respect to the person’s bond or attachment to society. Social control theory postulates that delinquent acts are often the result of people having a weak or broken bond to their society. This means that when people are less attached to others, they are more prone to deviating from social norms and standards. Since they no important relationships with other people, they really have nothing to lose, therefore, it becomes very easy for them to commit a crime. The life course perspective of Sampson and Lab basically offers the same path of explaining how informal social relations can affect a person’s commitment to his society. They say that the attachment or bond that a person develop throughout life with his spouse or coworkers makes a person more committed to his society. He loses his motivation to deviate or to commit an offense because Of the social bond he has developed mainly due to her concern for his spouse or coworkers. How to cite Criminology Paper, Papers

Florida- Blind, Deaf, and Dumb free essay sample

Coleman already knew one thing for sure about his future, and that was that he wanted to make educating children his life’s work. Coleman knowing about the lack of educational decrees in Florida decided to take the opportunity to advantage, by writing to Governor William D. Bloxham asking for a sum of $20,000 minimum appropriation to start a school for the deaf and blind. Coleman’s hopes came true when in 1883 Florida’s legislature establishes an institution for blind and deaf children for two years at $20,000. The location of the school was put to a biding between the towns in Florida. Captain Edward E. Vaill offered St. Augustine the biggest bid of $1,000 and 5 acres. The original three wood buildings were erected by contractor William A. MacDuff at $12,749. The school was completed in December 1884. The first class entered in 1892 with 62 students. The two first graduates were both deaf, their names were Artemas W. We will write a custom essay sample on Florida- Blind, Deaf, and Dumb or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Pope of St. Augustine and Cora Carlton of Island Grove. The two later married and became parents of Florida Senator Verle A. Pope. The first blind student graduated in 1908. The first African American graduates were Louise Jones a blind student in 1914, and Cary White a deaf student in 1925. The school originally only had 5 trustees in 1905, until 1963 were there were 7. Taylor Hardwick began construction on new dormitories in late 1958 and opened in 1959. The school is now the largest of its type in the U. S. The school now has 47 buildings and 72 acres. The school’s annual budget is over $30 million dollars. The schools no longer an boarding school but, now a public school. It’s the only school in Florida that is pre-school through 12th grade. It also has a post-secondary program. The school is accredited by the Southern Association of Colleges, and Schools. The Conference of Education Administrators serving the deaf, and the National Accreditation Council for Agencies Serving the Blind and visually handicapped. The school has two departments: the Deaf department, and the Blind department. The school also has outreach programs for parents, teachers, and other staff in small and rural school districts in Florida. The also has a healthcare center on campus for students, as well as two well-appointed auditoriums. The school boasts the Copeland recreation and fitness center, which is specially designed and constructed for the blind. The center is the site of the annual USABA’s youth national goalball tournament. Not only that but blind high school students get state of the art sound system within the school. The school has 11 sports you can join at the school: Football, Soccer, Volleyball, Basketball, Little League Baseball, Track, Cross Country, Swimming, Goalball, Wrestling, and Cheerleading. They have preforming arts groups, the deaf department has a traveling dance troupe, and the blind department has a band known as the OuttaSight. The school also has several clubs: the blind skier, academic bowl team (competitive), and a traveling math club called MathCounts. -Notable Alumni- * Ray Charles- He learned to read braille here. When he went to the school it was known as the Institute for the Blind, Deaf and Dumb. * Ashley Fiolek- A very well-known rider in motocross racing. * Marcus Roberts- A famous Jazz pianist. -My Perspective- I really enjoyed researching and writing this essay. Originally the essay was supposed to be about all deaf culture related things in Florida but, as I started one of the things that kept popping up was the Florida school for the Deaf and Blind. Since it kept popping up I clicked on it and was amazed that it was in St. Augustine (which is where I was going to go for spring break), and that it was the oldest school for the deaf in Florida. All of a sudden I knew that I wasn’t doing my project on the deaf culture in Florida but instead a certain school for the deaf in Florida. Then I realized I had to make a decision; the schools name is the school for the Deaf and Blind. Meaning I would have to decide if I wanted to do my project on the school as a whole which means the Deaf and Blind, or just the Deaf department. As you already know (because hopefully you read the essay) I choose to both. The reason I choose to do both is because if I’m writing (or typing) this essay about the school than I’m going to write about the school in a whole. When I saw the school in person was when I finally realized just how big 47 buildings and 72 acres is. the school is huge and looked like it could swallow are school times two. I wasn’t able to go into the school. I was also surprised that I didn’t see that many people who were either deaf or blind from what I could tell at least. I do remember seeing this one girl who was deaf a couple times, I think she might have been a tourist though because I saw her at a tourist spot. The first time I say her we were sitting across from each other at a restaurant. My dad kept telling me to go say hi, and I swear I told him a million times that I couldn’t and that it would be considered rude. All in all I feel extremely pleased with what I came up with for this essay, and I hope you are too.